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While the functions of the HEAT-repeats are relatively well-understood 21 , the roles of the IDR, due to its structural flexibility, which prevents its visualization in cryo-EM structures, remains largely unclear 20

We confirm that, despite being truncated, Rv1127c is a functional histidine kinase that fine-tunes the MCC by interacting with the enzymes of this pathway

doi: 10.1007/s12576-016-0459-y 84 Blanco-RiveroJSagredoABalfagnGFerrerM

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