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When the liver is damaged, inflammation and oxidative stress are produced, HSCs are activated, a large number of collagen fibers are produced, and fiber degradation is inhibited, resulting in excessive deposition of ECM and liver fibrosis

Maes M, Jirakran K, Semeo LO, Michelin AP, Matsumoto AK, Brinholi FF, Barbosa DS, Tivirachaisakul C, Almulla AF, Stoyanov D, Zhang Y

doi: 10.1182/blood-2013-03-493163 71 EmadiAJunSATsukamotoTFathiATMindenMDDangCV

Song R, Ma S, Xu J, Ren X, Guo P, Liu H, et al

therefore, rapid identification of safety concerns and unknown side effects are made possible (EMA, 2020a)

Dutra AV, Lin HF, Juo SH, Boyadjis M, Moussouttas M, Reddy PL, Grewal RP: Analysis of the endothelial nitric oxide synthase gene as a modifier of the cerebral response to ischemia