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are co-founders of Ousia Pharma, a biotech company developing therapeutics for treatment of obesity

Gomes AC, Hoffmann C, Mota JF

Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)

Thats why subcutaneous injection of large doses (5-10 mg) is the standard delivery method in most epithalon protocols: you have to flood the system to get enough surviving peptide into target tissues before degradation wipes it out