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Since such a first cycle arrest is typical for agents that break DNA 30 and because HANs were linked with DNA breaks in mammalian cells 10 , we tested whether they increase the phosphorylation of histone 2AX at S129 by Rad3 and Tel1, an established marker of chromosomal breaks 31

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Oecologia 103:518522

Trends Pharmacol Sci 40:577591

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