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This result is consistent with data from a single-cell sequencing study which specifically profiled cells isolated from the adult mouse cerebellum [28]

Further studies showed that SLC7A11 regulated ferroptosis in lung cancer mainly by regulating metabolic demand [77]

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Funding This work was supported by a Medical Research Council award (COEN-Centres of Excellence for Neurodegeneration MRC/S004920/1) to PJS, RJM and MC and by the MND Association AMBRoSIA (A multi-centre biomarker resource resources strategy for ALS) programme (Oct15/972797) to PJS, MRT and AM

On the other hand, inhibition of GSH synthesis with BSO, independently of the cysteine pool, has been repeatedly described to induce ferroptosis ( via depletion of mitochondrial GSH pool leading to the release of cytochrome c, when combined with chemotherapy in breast cancer and leukemia, respectively (71, 72)