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doi:10.1113/expphysiol.2004.029462 48

While both the classic and trans-signaling receptor complexes activate similar intracellular signaling pathways, emerging evidence suggests that classic signaling is essential for the anti-inflammatory and regenerative effects of IL-6, whereas IL-6 trans-signaling tends to promote pro-inflammatory responses

found that the lack of sFRP4 is one of the causes of cortical bone thinning

These ILVs are subsequently released as Exos when the MVBs fuse with the plasma membrane [47, 50, 66] (Fig

(2024) 19:e0314750

mtDNA proximity to these ROS production sites makes them more vulnerable to damage, mutations, deletions, and genetic instability [16]