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The Phase II denomination comes from Williams classic nomenclature and can be misleading, as it reflects the notion of sequential metabolism, where the parent drug is converted to a primary (or first-generation) metabolite, which in turn is subjected

TABLE 7 Summary of parameters in the PBPK model

In two separate case reports, one newborn (2 months old) with early infantile Leigh-like SLC19A3 gene defect (129) and one (30 days old) with THTR2 deficiency (130) responded dramatically differently to thiamine supplementation

If you're using the same dosing schedule for both, one accumulates peptide while the other doesn't, and your dose-response curve becomes meaningless

The goal is not to replace a nurse-delivered IV visit

Early recognition and diagnosis are important