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6.1 Optimization of pharmacokinetics and nanocarrier delivery Phytochemicals often face significant pharmacokinetic challenges, such as poor solubility, rapid metabolism, and low bioavailability, which severely limit their clinical application

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Just because something is discovered and given a name, does not mean its mechanism is understood

Preclinical research models indicate that MPs/NPs may accelerate both the initiation and progression of PD by facilitating -synuclein misfolding and aggregation, triggering neuroinflammatory cascades, elevating oxidative stress, and impairing mitochondrial function