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As a macromolecular molecule, APS are insoluble in water, have a low oral absorption rate and a low bioavailability, and are quickly affected by stomach acid and other variables, resulting in a highly limited therapeutic effectiveness

If not quickly treated, these symptoms can lead to anaphylactic shock and death

10.1038/s41388-020-1355-8 325 ShimbaS.OgawaT.HitosugiS.IchihashiY.NakadairaY.KobayashiM.et al (2011)

3 , e01607 (2013)

Any visible bits, flecks, or debris mean it is time to discard the vial

Additionally, their satisfactory optical properties and low toxicity render them as suitable fluorescent probes for biological imaging