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The initiation of necroptosis can also be influenced by adjusting upstream signaling pathways, such as using the sphingosine analog FTY720 (fingolimod), which triggers necroptosis in human lung cancer cells by interacting with the I2PP2A/SET oncoprotein and activating the PP2A/RIPK1 pathway (Saddoughi et al., 2013)

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doi: 10.31857/S0026898423060228 166 ZhaiC.-Z.ZhaoL.YinL.-J.ChenM.WangQ.-Y.LiL.-C.et al

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