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(This also explains why aqueous-solubility models outperformed intrinsic-solubility models on the intrinsic-solubility test sets.) Nevertheless, using to predict pH-dependent solubility gives a good qualitative match with experiment, excepting cases where ion aggregation leads to lower-than-expected solubility

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We are finalizing our proposed amendment to the regulations to reflect this data collection requirement at 42 CFR 413.20(d)(3), without modification