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Yan and their team found that a high-fat diet causes intestine Treg cells to undergo ferroptosis, which may be the primary first step in immunotolerance loss and colitis development (199)

This resulting neuroinflammation directly impairs the brainstem's ability to properly regulate heart rate, blood pressure, and vascular tone, directly leading to the severe tachycardia, debilitating dizziness, and painful blood pooling characteristic of POTS

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Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression

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