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In Huntingtons disease, caused by polyglutamine expansions in the Huntingtin protein, curcumin reduced photoreceptor degradation and motor impairment in Drosophila models (413)

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In this study, taking advantage of a panel of in situ hybridization (ISH) probes targeting the marker genes for different stages of OL lineage cells, including Pdgfra, Plp, Mbp, Mog, and especially the recently reported maker gene for newly forming OLs, namely Enpp6 , with the combination of immunofluorescence staining of CC1, SOX10, we provide a temporally detailed dynamic profile of OL lineage cells in the currently most commonly used standardized acute CPZ demyelination model of 5 weeks feeding followed by 4 weeks recovery