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invasive adenocarcinomas)

Current clinical management strategies, including conservative and surgical treatments, aim primarily to alleviate symptoms rather than reverse the pathological process or promote structural regeneration of the intervertebral disc (IVD)

222,227 Signaling pathways linked to AD pathogenesis Neuroinflammatory signaling Several pathological factors in AD, such as A, pro-inflammatory cytokines, and oxidative stress, activate microglia and initiate downstream signaling pathways such as MAPK, NF-B, and PI3K/Akt

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