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Frizziero A, Vittadini F, Barazzuol M et al (2017) Extracorporeal shockwaves therapy versus hyaluronic acid injection for the treatment of painful non-calcific rotator cuff tendinopathies: preliminary results

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This indicates that sensory nerves in brown adipose tissue are likely to form a feedback loop with sympathetic nerves, coordinating sympathetic neurotransmitter thermogenesis, promoting sympathetic thermogenesis when ambient temperature or local tissue temperature is too low, and inhibiting sympathetic thermogenesis when the temperature is too high, thus adapting to ambient temperature (131, 132)

This involves the recommended dose and knowing the best time to take it

Neurological symptoms may take several months or even years to resolve completely