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"Photoaging therapy with topical tretinoin: an evidence-based analysis." Journal of the American Academy of Dermatology

El Sayes, et al

Nasal spray: Yes, easily portable with no special storage needs

For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)