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Of note, like NOX-mediated ROS, which can modulate IL-1 expression (Warnatsch et al., 2017), mitoROS can also modulate the antimicrobial functions of innate immune cells by regulating production of multiple cytokines both in vitro and in vivo (Mills et al., 2016

The expression levels of genes involved in neuronal and oligodendrocyte maturation, and angiogenic and transport functions were altered, reflecting enhanced brain maturation in response to IGF-1 treatment

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At the study completion, the primary endpoint at week 4 was similar between treatment groups (38.1% vs

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