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However, it is known that ER predominates in dermal cells and the expression of ER declines after menopause with the loss of collagen and elastin

Influence of water and nitrogen deficit on fruit ripening and aroma potential of Vitis vinifera L

Suwalsky M, Hernndez P, Villena F, Aguilar F, Sotomayor CP

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10.1016/j.ejphar.2007.05.072 69 TodaN.NakanishitodaM

If levels of glutathione are low or the pathway is overwhelmed by high doses of acetaminophen, the reactive intermediate accumulates and binds to intracellular macromolecules that can lead to cell injury, usually through apoptotic pathways