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This process, called proliferation, requires energy, building blocks, and cofactors to produce the many cells and substances needed to mount an effective immune response

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For example, sulforaphane from broccoli is a well-characterized inhibitor of histone deacetylase (HDAC) enzymes, while the catechin epigallocatechin-3-gallate (EGCG) abundant in green tea is known to inhibit DNA methyltransferases (DNMTs) 18,19

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Defects in pyrimidine synthesis most commonly present as an increase in orotic acid in the urine