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Crohns M, Saarelainen S, Erhola M, Alho H, Kellokumpu-Lehtinen P

* **Uncommon Side Effects:** Though rare, some individuals might experience more serious side effects

Evidence supports select use, not routine use

Unfortunately, these substances can induce harmful effects on cells and tissues and even promote oxidative stress that generates lipid peroxidation, damage of deoxyribonucleic acid (DNA), and enzyme inactivation, including free radical scavenger enzymes [6]

Discussion Radiation-induced proctitis remains a challenging complication of pelvic radiotherapy, for which effective and well-tolerated local treatments are still limited [1, 5]

Therefore, we next examined whether the cytoprotective effects of MAPKAPK2 under oxidative stress are dependent on its kinase activity by using a selective MK2 pharmacological inhibitor (PF-3644022)