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10.1016/j.cca.2012.06.022 6 AssavarittirongC.SamborskiW.Grygiel-GorniakB

Like endogenous BPC, it exhibits powerful cytoprotective properties, fortifying, protecting, and healing the lining of the GI tract

Several factors, including tissue context and the exact cellular mechanisms driven by succinate, appear to be major determinants in either response

The result is a systems-level approach to digestive health, with butyrate at the center as the key metabolite.

Gentamicin-induced nephrotoxicity triggers inflammation by activating the NF- transcription factor, which subsequently induces the production of pro-inflammatory cytokines IL-6 and TNF- 74,75 which in turn can exaggerate oxidative stress by producing more reactive oxygen species 32

Insulin and thyroid hormones are also potent modulators of the HPG axis (2225)