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On the most basic level, cancer is the result of normal cells growing unchecked, an observation that led researchers to speculate that specific genes or gene mutations enable this to occur

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The availability of published clinical data has accelerated adoption in regulated markets including the United States, Canada, and Western Europe, where regulatory authorities require substantiation for efficacy claims

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Although direct evidence of trained immunity in clinical AD is still limited, transcriptional, epigenetic, and metabolic alterations observed in immune cells, including microglia, monocytes, and dendritic cells, from both patients and animal models are consistent with mechanisms underlying innate immune memory