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Hum Genet 138:13591377 Schiff MH, Jaffe JS, Freundlich B (2014) Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses 15 mg may be overcome with subcutaneous administration

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The variations in standard methodology in feed formulation, dosage of synbiotics, stages of fish, treatment period, route of administraton, selected fish type, and environmental conditions, and effectiveness of synbiotics have contributed to the major complexities of the field