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Zhang S, Li X, Zhang F, Yang P, Gao X, Song Q (2006) Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structureactivity relationship of potent inhibitory activity against DNA topoisomerase I

The regulator did not find any issues with the safety or benefit/risk profile of Izervay through two years

Whilst the true (not anecdotal or case reports) effects on melasma are lacking via large studies there are some reports that it can help with melasma pigmentation, especially in combination with procedures such as lasers & novel chemical peels

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Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells