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Further research indicates that CSAI is particularly effective for patients with motor fluctuations and severe insomnia [151]

Acknowledgements We acknowledge the financial support from the National Natural Science Foundation of China (Z.T., 52002314 and Y.Q., 21872109)

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Thus, since otherwise inescapable somatoneuron depletion following a capsaicin application could completely be avoided with a daily NaBPC157 application, it is possible that the effects of NaBPC157 could be related specifically to the integrity of capsaicin sensitive somatosensory neurons and their protection (i.e., primary afferent neurons having small diameter somata and unmyelinated (C-) or thinly myelinated (A-8) fibers)