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Highlighting the potential of this approach, several recent translational and clinical studies beyond the field of MS used this method of delivery and were able to clear intracellular tau pathology in tauopathy mice by intranasal application of an anti-tau-antibody (144) or reduce apathy in frontotemporal dementia patients by intranasal application of oxytocin (149) ( Figure 2C )

Linseed oil, which contains n-3 PUFAs, especially alpha-linolenic acid (ALA), has been shown to reduce body weight increase and visceral fat

One study in the Journal of Affective Disorders found that adding zinc to antidepressant treatment improved symptoms significantly more than antidepressants alone

Since alcohol is less soluble (less able to dissolve) in fat and more soluble in water, this difference can result in higher BAC levels in women than men even if they consume the same amount of alcohol

[DOI] [PubMed] [Google Scholar] 146.Taylor FL, Levine LA