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Hydroperoxides can then be reduced to form hydroxyl intermediates (HETE and hydroxy-octadecadienoic acid (HODE)) and further dehydrogenated to form ketone intermediates (oxo-eicosatetraenoic acid (oxoETE) and oxo-octadecadienoic acid (oxoODE)) ( Reference Yuan, Rapoport and Soldin 62 )

Curcumin protects neuronal cells against status-epilepticus-induced hippocampal damage through induction of autophagy and inhibition of necroptosis

Maybe bioavailability is the culprit

The multidimensional mechanisms of hyperbaric oxygen (HBO) therapy in cerebral ischemic-hypoxic injury are becoming increasingly elucidated

Moreover, the specific peroxidation of PE phospholipids during ferroptosis may serve to counter the buffering effect of PE on membrane curvature, area per lipid and membrane thickness, initiating the ferroptosis process at the sites that would otherwise be maintaining membrane integrity

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