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Nat Prod J 15(5):E200624231105

The inclusion criteria included original experimental studies (e.g., in vitro cell culture, animal models, and human studies)

It also supports regeneration of vitamin C, helping protect cells from oxidative stress

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

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These suggests that the neuroprotective effects of berberine may be related to an excitatory mechanism that promotes cell survival and antioxidant-related signaling pathways