(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: In the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controls Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissue For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: We report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice
Dos SantosFARXavierJAda SilvaFCMerlinJPJGoulartMOFRupasingheHPVet alAntidiabetic, antiglycation, and antioxidant activities of ethanolic seed extract of Passiflora edulis and piceatannol in vitro
Storage Stability: Maintains reconstituted peptide integrity longer than non-preserved sterile water alternatives, which is critical for multi-week studies
doi: 10.1038/s41586-019-1237-9 118 MatsusakiTTakedaSTakeshitaMArimaYTsend-AyushCOyunsurenTet al
In line with this evidence, a recent study demonstrated that the cytosolic DNA sensor cGAS, through activation of the cGASSTING pathway in microglia, amplifies neuroinflammation and dopaminergic neurodegeneration in neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced models of PD, highlighting this axis as a potential therapeutic target [223]
Additionally, baicalein, an active component from the traditional Chinese medicine Scutellaria baicalensis, functions as a potent iron chelator and inhibits erastin-induced Fe 2+ production under normal cellular conditions, potentially playing a key role in regulating organismal iron homeostasis and inhibiting Fenton reactions (71)
