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Nat Med (2014) 20(10):114756

In the same study a significant increase in DNA repair enzymes (poly-ADP-ribose polymerase levels), a disappearance of DNA methylation patterns (RASSF1A DNA methylation pattern), and a reduction of pro-angiogenic marker levels were observed, suggesting an improvement of the prognosis [94,95]

An interesting study has cross-validated the two seeding assays, RT-QuIC and PMCA, to measure o--syn in the CSF of PD patients and healthy controls [116], describing reliable and reproducible results for the diagnosis of PD