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Collectively, these findings underscore mitochondria as central therapeutic targets in parasite-host interactions

[DOI] [Google Scholar] 139.Wang W., Wu N., Zu Y., Fu Y

10.1016/j.neuropharm.2015.09.015 23 BaltanS.BesanconE

Therapeutic applications Given the dependence of cancer cells on glutamine metabolism, targeted therapies have been developed against glutamine metabolism, from glutamine uptake to glutamine-catalysed enzymes

BAEC were transfected with duplex siRNA targeted against PKA (PKA siRNA) or a random sequence (scrambled siRNA)

The lactate signaling pathway primarily targets ATP-sensitive potassium (K-ATP) channels to regulate neuronal firing, with these channels being a key target for lactate signaling (Karagiannis et al., 2021)