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This is associated with impaired mitochondrial function, dysregulated OXPHOS, and increased ROS

Remember when we mentioned how this interaction is one of the strongest natural interactions observed so far

Nat Rev Cardiol 8(9):485493 Deswal A et al (2001) Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST)