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Munc13-4 deficiency causes familial hemophagocytic lymphohistiocytosis type 3 (FHL3), an immunodeficiency driven by defective exocytosis in cytotoxic T lymphocytes, natural killer cells and neutrophils 17

doi: 10.1016/j.biopha.2024.116632 271 (PDF) Studying the Relationship Between Oxidative Stress Malondialdehyde and Heamatological Parameters in patients With Asthma in AL-Muthanna Province-Iraq

Oxidative stress interventions also face mechanistic ambiguities: GSH only partially rescues ovarian follicle loss, suggesting incomplete understanding of redox balance in follicular survival (Hohos et al., 2020), while melatonins ability to ameliorate age-related meiotic defects via the SIRT2-dependent H4K16 deacetylation pathway requires deeper exploration to define its broader applicability (Wu et al., 2024)

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