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Probiotic-fermented pueraria lobata (Willd.) ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

Ruggenenti, P., Cattaneo, D., Loriga, G., Ledda, F., Motterlini, N., Gherardi, G., Orisio, S., and Remuzzi, G

Because the disulfide bridge (a cyclic disulfide) can undergo redox reactions, during the reactions catalyzed by the pyruvate dehydrogenase complex it is first reduced to dihydrolipoamide, a dithiol (the reduced form of the prosthetic group), and then reoxidized to the cyclic form

The balance hinges on source identity , subcellular location , chemical species and timeamplitude of the ROS pulse