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10.1016/j.freeradbiomed.2017.05.002 Free Radic

N3 is the representative peptidomimetic inhibitor, and harbours a Michael acceptor as a warhead and substituents spanning all substrate-binding subsites

Bottom line: the largest weight-loss signal of any obesity peptide so far about 24% mean loss at 48 weeks in a phase 2 trial but investigational only, now in phase 3 (the TRIUMPH program) and not approved by any regulator

4F, SRF robustly increased the luciferase activity of PARN -WT but failed to enhance the activity of PARN -MUT, indicating that SRF directly binds to the PARN promoter