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The combination of these two medications has led to significant weight loss and improved glycemic control during clinical studies

Compared to non-HCC ICI, HCC-ICI and HCC-Sorafenib were more often male (57%, 82%, 77%), Hispanic (14%, 35%, 34%), and cirrhotic (1%, 85%, 88%)

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These metabolic and proteomic changes collectively indicate that in ATP6AP1 KO cells show a metabolic phenotype protected from ACT-induced rerouting of carbons, suggestive that partial v-ATPase disruption appears to reduce cellular reliance on mitochondrial oxidation, enabling resistance to mitochondrial insults while limiting biosynthetic capacity