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Either biofilm might grow on the abiotic surfaces that include knee replacements, implants, dental units, catheters, contact lenses, screws, pins or prosthetic valves and joints or they are host tissue related that leads to chronic wounds, endocarditis, cystic fibrosis lings or chronic otitis media (Sharma et al., 2019)

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Consistently, in vitro experiments using primary PTECs treated with 6 mM CaOX for 10 or 20 h showed increased ACSL4 levels and decreased FSP1, GPX4, and KEAP1 levels (Fig