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Jankowska EA, Kasztura M, Sokolski M, Bronisz M, Nawrocka S, Olekowska-Florek W, et al

Plotz P

while some patients report subtle shifts in energy within a few weeks, it typically takes 2 to 3 months of daily supplementation to sufficiently replenish deep intracellular nutrient deficits and observe meaningful changes in baseline fatigue

[Abstract]2023 Jul;39(7):699-709

doi: 10.1007/s12035-021-02635-z

The medications most commonly associated with B12 deficiencies include metformin (diabetes), antacids, anti-ulcers, blood pressure, cholesterol meds, and birth control pills (12, 13)