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Exp Lung Res 36:548557

Interestingly, there are no known transmembrane transporters for NADP+ or NADPH, meaning the relative pools in each subcellular compartment are likely generated and consumed locally

ROS can induce AP-1, a heterodimer composed of c-fos and c-jun, which downregulates type I collagen and upregulates MMPs in aging skin [77], and can also inhibit the TGF- signaling pathway in skin fibroblasts

These cytokines, associated with activated polymorphonuclear leukocytes (PMNs) and their derived proteases, destroy newly developing tissue and degrade key growth factors

Hence, these results suggest that the decline in oxidative stress due to cold stress was ameliorated by GSH treatment which could be due to enhanced antioxidant capability thereby increasing stress tolerance observed in GSH-treated plants

doi: 10.1038/cddis.2017.480