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In the same study, increased levels of transforming growth factor-beta (TGF-), a cytokine known to reduce the expression of GCL, were observed in plasma samples from T2DM subjects when compared to the healthy group

COV m , the median value of covariable in the population

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Although this proportion is broadly consistent with that observed during substantial weight loss induced by lifestyle interventions or other obesity management therapies, it is not negligible and warrants careful consideration