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While it was long assumed that patients simply suffered from systemic glutathione depletion, a landmark 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) uncovered a more complex reality

Across multiple independent cohorts (Table 1), UC is consistently associated with increased relative abundance of Proteobacteriaparticularly the Enterobacteriaceae alongside reduced levels of health-associated groups such as Bifidobacterium , Lachnospiraceae, and Verrucomicrobia (e.g., Akkermansia

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Cerella C, Coppola S, DAlessio M, De Nicola M, Magrini A, Bergamaschi A et al

While short-term inflammation is a necessary part of the healing process, chronic inflammation can lead to tissue damage

K.MoselerA.SchwarzlnderM.et al (2019)