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If your diet is already high in other sulfur-rich foods (like garlic, onions, and cruciferous vegetables) or common reflux triggers (like spicy foods, caffeine, or alcohol), adding glutathione might be the straw that breaks the camels back.

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Other factors that might mean more plain water include: Activity level: If you're losing water through sweat because you're exercising, you should increase your water intake

Regardless, the clinical safety in humans is still largely unknown