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The study protocol was approved by the Ethics Committee of Minzu University of China and followed the guidelines of the Declaration of Helsinki

The results showed that the overexpression of ATP6AP1L gene with pcDNA3.1-GST DAF -ATP6AP1L and pcDNA3.1-GST CEAM7 -ATP6AP1L could significantly inhibit the proliferation of K-562 cells compared with the control cells transfected with empty vectors, pcDNA3.1-GST DAF, and pcDNA3.1-GST CEAM7 , respectively

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Therefore, understanding whether IF can mitigate these factors by improving both inflammatory and oxidative stress markers, as well as liver enzyme profiles, could offer a novel, non-pharmacological strategy for managing RA and its associated metabolic complications in this vulnerable population

Finally, many thankful regards go to Jorgete Constantin, Aparecida Pinto Munhos Hermoso and Renato Polimeni Constantin, from the University of Maring, Paran, Brazil, for their invaluable help during some experimental procedures

Store the lyophilized vial as instructed on the label, and store any reconstituted solution under the recommended conditions and timeframe