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Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2 + homeostasis

Given that SOD1 is highly expressed in most of intracellular compartments, an immunohistochemical method using anti-SOD1 antibodies may be suitable for detection of pathological changes occurring in wild-type SOD1 only if the protein is densely accumulated as inclusion bodies

Prader-Willi Syndrome Treatment Prader-Willi syndrome is a genetic disorder that causes poor muscle tone and consistent feelings of hunger

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In summary, this study not only uncovered potential target proteins for DP in the treatment of sciatica but also provided crucial evidence for its mechanism of action, suggesting that DP may effectively alleviate sciatica by downregulating IL-6 and CINC-3, inhibiting neutrophil migration, and upregulating CNTF to promote neurotrophic effects