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J Dis Med Plants

Notably, the presence of cysteine residues is critical for efficient Ht protein delivery, with an insulin B chain mutant showing superior efficacy in transporting cargo proteins, highlighting the potential of IR- and IGF1R-mediated transport systems for CNS drug delivery (Table 6) [144]

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The hyperglycemia that results from simultaneous inhibition of InsR signaling could be overcome through the design of more selective inhibition strategies, for instance inhibitors that target IGF-1R over InsR (perhaps through allosteric mechanisms)

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