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These came up short of expectations, but there were also winners -Bristol Myers Squibbs LAG3 (Opdualag) + CTL4 (Yerovy), both of which are expected to be multi-billion dollar drugs

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Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous