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194 Aging-related alterations in the gut microbiota promote the development of systemic inflammation, which can have profound effects on disease, either directly or indirectly

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However, supplementation may bring some side effects

Appl Biochem Biotechnol 190 , 487505 (2020)

Gut health is most important because if your gut is healthy digestion is good which leads to good absorption and healthy nourishment of the body

For instance, aerobic exercise significantly increases GABA receptor subunit expression (2, 5, 2) in the prefrontal cortex and hippocampus, contributing to improved mood regulation [114]