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Moreover, chronic stress is associated with increased metabolic demand, which can deplete the bodys stores of B vitamins , necessary for nervous system function and stress hormone production

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Notably, the anti-inflammatory effects of GA were abolished by Nrf2 inhibition, suggesting a Nrf2-dependent mechanism (Zhang et al., 2022), although direct suppression of inflammatory mediators was not explicitly demonstrated

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A more insidious onset or progression over more than two weeks should prompt reconsideration of the diagnosis

A photocleavable masked nuclear-receptor ligand enables temporal control of C