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Tissue-specific Gclc KO in mice has identified important functions for GSH in physiological settings 8,9,10,11,12,13

Peroxynitrite content was expressed in umol/mg protein

Intersectional effects were found such that high ADI, female participants had the greatest temporal UWMC on the additive (relative excess risk due to interaction=0.72, 95% CI=[0.11,1.32]) and multiplicative (p-interaction=0.04) scales

Since the treatment involves infusion through a needle, bruising, tenderness, and pain at the injection site may occur, and allergic reactions may also occur

Animal model and experimental protocol Male C57BL/6 mice (8 weeks old) weighing 25 0.5 g were obtained from the Jackson Laboratory (Bar Harbor, ME)

$350 for 1 month (4 weeks) or $605 for 2 months (8 weeks)