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87 p53 has also been reported to negatively regulate ferroptosis, p53 limits erastin-induced ferroptosis in colorectal cancer cells by promoting the nuclear localization of dipeptidyl peptidase 4 and increasing the expression of SLC7A11

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Biochem J 122:1318 Sokoloff L (1973) Metabolism of ketone bodies by the brain

Since similar enhancement of collagen synthesis was shown for the tripeptide in complex with copper (see below) it was not clear whether the activity was intrinsic to GHK or whether it was resulting from the formation of active copper complexes due to the presence of copper ions in the tissue culture medium

1) for which the human in vivo metabolic fate of the amide bond had previously been characterised, alongside 15 exemplar aromatic amides